Dr. Xianfeng (Jeff) Chen currently is a Computational Systems Biologist and Principal Investigator (DoD DB 04 / GS 14) at ERDC, and Chief Scientific Officer of IFXworks Corporation. Jeff's scientific strengths include genome annotation, network analysis, functional and comparative genomics, proteomics profiling, micro-array transcription profiling, biological databases and data integration, biological system simulation and modeling. During the course of his academic and industrial careers, Jeff was personally responsible for assembly and analysis of over 170 microbial and 5 plant genomes, mouse and human genomes, and also assembled human genome-scale protein-protein interaction networks, as well as conducted research in target discovery for treatment of colon cancer. Dr. Chen has authored over 30 publications in scholarly and professional journals and over 20 US and world patents. Before founding IFXworks and joining ERDC, Dr. Chen was Assistant Professor at the University of Virginia School of Medicine , Research Investigator and Project Manager of Proteomics Cyber-infrastructure in the NIH/NIAID National Biodefense Program on Human Pathogens, Virginia Bioinformatics Institute, and also a Bioinformatics Program Consultant to Battelle Memorial Institute. Prior to his academic career, Jeff worked for Prolexys Pharmaceuticals and Monsanto Companies. Jeff holds a Doctorate in Genetics and a Master (equivalent) in Computer Science, both from Iowa State University, and a Master's degree in Biochemistry from the Chinese Academy of Sciences.


Selected Relevant Publications (Out of over 30 Publications) :
  1. Carlos M. Hernandez-Garcia, Robert A. Bouchard, Paul J. Rushton, Michelle L. Jones, Xianfeng Chen, Michael P. Timko, and John J. Finer, 2010. Rapid validation of 20 different soybean (Glycine max) promoters in transiently- and stably-transformed tissues. BMC Plant Biology, submitted.
  2. Michael P. Timko, Paul J. Rushton, Thomas W. Laudeman, Marta T. Bokoviec, Edmond Chipumuro, Foo Cheung, Christopher D. Town, and Xianfeng Chen, 2008. Sequencing and Analysis of the Gene-Rich Space of Cowpea. BMC Genomics. 2008, 9:103.
  3. Paul J. Rushton, Marta T. Bokowiec, Thomas W. Laudeman, Jennifer F. Brannock, Xianfeng Chen, and Michael P. Timko, 2008. TOBFAC: The Database of Tobacco Transcription Factors. BMC Bioinformatics. 2008, 9:53.
  4. Paul J. Rushton, Marta T. Bokowiec, Shengcheng Han, Hongbo Zhang , Jennifer F. Brannock, Thomas W. Laudeman, Xianfeng Chen, and Michael P. Timko, 2008. Bioinformatics Analysis on Tobacco Transcription Factors: Novel Insights into Transcriptional Regulation in the Solanaceae. Plant Physiology. 2008, 147:280-295.
  5. Xianfeng Chen, Thomas W. Laudeman, Paul J. Rushton, Thomas A. Spraggins, and Michael P. Timko, 2007. CGKB: An Annotation Knowledge Base for Cowpea (Vigna unguiculata L.) Methylation Filtered Genomic Genespace Sequences. BMC Bioinformatics. 2007, 8:129.
  6. Guoqing Lu, Liying Jiang, Resa M. Kotalik, Thaine W. Rowley, Luwen Zhang, Xianfeng Chen, and Etsuko N. Moriyama, 2006. GenomeBlast: A Web Tool for Small Genome Comparison. BMC Bioinformatics. 2006, 7 (Suppl 4):S18.
  7. Xianfeng Chen and Reid G. Palmer, 1998. Genetic instability at the k2 Mdh1-n y20 chromosomal region in soybean. Molecular Genetics and Genomics. 260:309-318.
  8. Xianfeng Chen, John Imsande, and Reid G. Palmer, 1999. Eight new mutants at the k2 Mdh1-n y20 chromosomal region in soybean. The Journal of Heredity. 90:399-403.
  9. Xianfeng Chen and Reid G. Palmer, 1998. Recombination and Linkage Estimation between the k2 and Mdh1-n y20 loci in soybean. The Journal of Heredity. 89: 488-494.
  10. Xianfeng Chen and Reid G. Palmer, 1996. Inheritance and linkage with the k2 and the Mdh1-n loci in soybean. The Journal of Heredity. 87: 433-437.
Selected Latest Patents in Synthetic Biology and Biotechnology (Out of over 20 Patents and Invention Disclosures) :