GRF Transcription Factor Family
A novel gene GROWTH-REGULATING FACTOR1 (OsGRF1) encodes a transcription factor that appears to
play a regulatory role in stem elongation. GRF proteins contain the characteristic regions- QLQ
(Gln, Leu, Gln) and WRC (Trp, Arg, Cys) - as well as features indicating a function in
transcriptional regulation. Most AtGRF genes are strongly expressed in actively growing and
developing tissues, such as shoot tips, flower buds, and roots, but weakly in mature stem and
leaf tissues. Overexpression of AtGRF1 and AtGRF2 resulted in larger leaves and cotyledons, as
well as in delayed bolting of the inflorescence stem when compared to wild-type plants. In
contrast, triple insertional null mutants of AtGRF1-AtGRF3 had smaller leaves and cotyledons,
whereas single mutants displayed no changes in phenotype and double mutants displayed only minor
ones. The alteration of leaf growth in overexpressors and triple mutants was based on an
increase or decrease in cell size, respectively. This indicates that AtGRF proteins play a role
in the regulation of cell expansion in leaf and cotyledon tissues.
38 predicted putative GRF TF peptide,
CDS,and cDNA sequences;
blast HSP, and multiple sequence alignment in
Soy - TFKB.
GRF domain peptide sequences with alignment and
phylogeny tree.
6 GRF protein
and DNA
sequences with
annotations for soybean in PlantTFDB. Most are partial sequences.
Last updated by Dr. Jeff Chen
on July 15, 2009.
