LUG Transcription Factor Family
Regulation of homeotic gene expression is critical for proper developmental patterns in both
animals and plants. LEUNIG is a key regulator of the Arabidopsis floral homeotic gene
AGAMOUS. Mutations in LEUNIG cause ectopic AGAMOUS mRNA expression in the outer two whorls
of a flower, leading to homeotic transformations of floral organ identity as well as loss of
floral organs. We isolated the LEUNIG gene by using a map-based approach and showed that
LEUNIG encodes a glutamine-rich protein with seven WD repeats and is similar in motif
structure to a class of functionally related transcriptional corepressors including Tup1
from yeast and Groucho from Drosophila. The nuclear localization of LEUNIG-GFP is consistent
with a role of LEUNIG as a transcriptional regulator. The detection of LEUNIG mRNA in all
floral whorls at the time of their inception suggests that the restricted activity of LEUNIG
in the outer two floral whorls must depend on interactions with other spatially restricted
factors or on posttranslational regulation. Our finding suggests that both animals and
plants use similar repressor proteins to regulate critical developmental processes.
(taken from TOBFAC).
Notes: LUG is missed in AtTFDB.
LUG protein sequences,
blast HSP, some are full length proteins and
CDS. The search was not specific to LUG.
10 LUG sequencs with confirmed domain based search.
Multiple
sequence alignment in Legume TFKB.
3 LUG sequences with annotations for
soybean in PlantTFDB. 2 seem to be partial sequences.
Last updated by Dr. Jeff Chen on May 23, 2009.